Allopregnanolone: A neurosteroid for managing acute and chronic pain conditions

acute and chronic maxillary sinusitis (nonodontogenic infection)

چکیده ندارد.

Acute Presentations of Chronic Pain Conditions

Managing acute and chronic pain in sickle cell disease.

Acute painful episodes among patients with sickle cell disease may occur in any body part or several sites simultaneously. The reasons for inadequate pain relief for this patient group are complex. Prompt, accurate pain assessment is the cornerstone of effective pain management and a comprehensive, multidisciplinary team strategy is essential, particularly for managing patients with frequent ac...

Neurosteroid allopregnanolone attenuates high glucose-induced apoptosis and prevents experimental diabetic neuropathic pain: in vitro and in vivo studies.

Hyperglycemia plays a critical role in the development of diabetic neuropathy. Hyperglycemia induces oxidative stress in neurons, resulting in neuronal cell apoptosis and dysfunction. Anti-apoptotic properties of neurosteroids have been demonstrated in numerous cellular models of neurodegenerative studies. Here, the protective effects of neurosteroid allopregnanolone were investigated in in vit...

Investigating and managing chronic scrotal pain.

Few data are available on the true incidence of chronic scrotal pain and most figures relate to post-vasectomy pain syndrome. However, a crude incidence of 350-400 cases of chronic scrotal pain per 100 000 men per year has been estimated on the basis of a questionnaire among Swiss urologists. Data on the impact of scrotal pain on quality of life are lacking. These patients are challenging to bo...